Genomic innovation of ATD alleviates mistranslation associated with multicellularity in Animalia
The emergence of multicellularity in Animalia is associated with increase in ROS and expansion of tRNA-isodecoders.tRNA expansion leads to misselection resulting in a critical error of L-Ala mischarged onto tRNAThr, which is proofread by Animalia-specific-tRNA Deacylase (ATD) in vitro.Here we show that in addition to ATD, threonyl-tRNA synthetase (